| Overview |
| bs-9001R-APC |
| SARM1 Polyclonal Antibody, APC Conjugated |
| WB, IF(IHC-P) |
| Human |
| Mouse, Rat, Dog, Cow, Pig, Horse, Rabbit |
| Specifications |
| APC |
| Rabbit |
| KLH conjugated synthetic peptide derived from human SARM1 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Store at -20C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 23098 |
| Q6SZW1 |
| SARM; SAMD2; MyD88-5; Sterile alpha and TIR motif-containing protein 1; Sterile alpha and Armadillo repeat protein; Sterile alpha motif domain-containing protein 2; SAM domain-containing protein 2; Tir-1 homolog; SARM1; KIAA0524 |
| Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38. |
| Application Dilution |
| WB |
1:300-5000 |
| IF(IHC-P) |
1:50-200 |
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