COPS6 Polyclonal Antibody
Applications
Reactivity
| Overview | |
| Catalog # | bs-9120R-100uL |
| Product Name | COPS6 Polyclonal Antibody |
| Applications |
ELISA
IHC-P
IHC-F
IF
|
| Reactivity | Human, Mouse, Rat |
| Specifications | |
| Conjugation | Unconjugated |
| Host | Rabbit |
| Source | KLH conjugated synthetic peptide derived from human COPS6 |
| Immunogen Range | 101-250/327 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles. |
| Target | |
| Gene ID | 10980 |
| Synonyms | JAB1 containing signalosome subunit 6;COP9 subunit 6 MOV34 homolog, 34 kD;MOV34 homolog, 34 kD;COP9 constitutive photomorphogenic, subunit 6; COP9 complex S6;COP9 signalosome complex subunit 6;COP9 signalosome subunit 6;cops6;CSN6;CSN6_HUMAN;hVIP;JAB1-containing signalosome subunit 6;MOV34 homolog;MOV34-34KD;Sgn3;SGN6;Signalosome subunit 6;VIP/MOV34;Vpr interacting protein;Vpr-interacting protein. |
| Background | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. |
| Application Dilution | |
| ELISA | WB1:300-5000 |
| IHC-P | 1:200-400 |
| IHC-F | IFIHC-P1:50-200 |
| IF | |
Frequently asked questions
Which applications is COPS6 Polyclonal Antibody (bs-9120R) validated for, and at what dilution?
bs-9120R is validated for WB (1:300-5000); IHC-P (1:200-400); IF(IHC-P) (1:50-200). These are recommended starting dilutions; optimal dilutions should be determined by the end user.
Which species does COPS6 Polyclonal Antibody (bs-9120R) react with?
Tested reactivity: Human, Mouse, Rat.
How should bs-9120R be stored?
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles. Storage buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
What immunogen was used to raise COPS6 Polyclonal Antibody (bs-9120R)?
KLH conjugated synthetic peptide derived from human COPS6 Immunogen range: 101-250/327.