COPS6 Polyclonal Antibody, AbBy Fluor-405 Conjugated
Applications
Reactivity
| Overview | |
| Catalog # | bs-9120R-BF405-100uL |
| Product Name | COPS6 Polyclonal Antibody, AbBy Fluor-405 Conjugated |
| Applications |
IF
|
| Reactivity | Human, Mouse, Rat |
| Specifications | |
| Conjugation | AbBy Fluor-405 |
| Host | Rabbit |
| Source | KLH conjugated synthetic peptide derived from human COPS6 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target | |
| Gene ID | 10980 |
| Synonyms | JAB1 containing signalosome subunit 6;COP9 subunit 6 MOV34 homolog, 34 kD;MOV34 homolog, 34 kD;COP9 constitutive photomorphogenic, subunit 6; COP9 complex S6;COP9 signalosome complex subunit 6;COP9 signalosome subunit 6;cops6;CSN6;CSN6_HUMAN;hVIP;JAB1-containing signalosome subunit 6;MOV34 homolog;MOV34-34KD;Sgn3;SGN6;Signalosome subunit 6;VIP/MOV34;Vpr interacting protein;Vpr-interacting protein. |
| Background | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. |
| Application Dilution | |
| IF | WB1:300-5000 |
Frequently asked questions
Which applications is COPS6 Polyclonal Antibody, AbBy Fluor-405 Conjugated (bs-9120R-BF405) validated for, and at what dilution?
bs-9120R-BF405 is validated for WB (1:300-5000); IF(IHC-P) (1:50-200). These are recommended starting dilutions; optimal dilutions should be determined by the end user.
Which species does COPS6 Polyclonal Antibody, AbBy Fluor-405 Conjugated (bs-9120R-BF405) react with?
Tested reactivity: Human, Mouse, Rat.
How should bs-9120R-BF405 be stored?
Store at -20C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. Storage buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
What immunogen was used to raise COPS6 Polyclonal Antibody, AbBy Fluor-405 Conjugated (bs-9120R-BF405)?
KLH conjugated synthetic peptide derived from human COPS6
What are the excitation and emission wavelengths of the AbBy Fluor-405 conjugate (bs-9120R-BF405)?
AbBy Fluor-405 on bs-9120R-BF405: excitation / emission 401nm/421nm.