KCTD11 Polyclonal Antibody
Applications
Reactivity
| Overview | |
| Catalog # | bs-9637R-100uL |
| Product Name | KCTD11 Polyclonal Antibody |
| Applications |
WB
ELISA
IHC-P
IHC-F
IF
ICC/IF
|
| Reactivity | Human, Mouse, Rat |
| Specifications | |
| Conjugation | Unconjugated |
| Host | Rabbit |
| Source | KLH conjugated synthetic peptide derived from human KCTD11 |
| Immunogen Range | 31-130/232 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles. |
| Target | |
| Gene ID | 147040 |
| Synonyms | C17orf36; MGC 129844; Potassium channel tetramerisation domain containing 11; REN; Retinoic acid EGF NGF induced gene protein; C 17 orf 36; KCD11_HUMAN. |
| Background | The KCTD11 gene encodes a protein that has been identified as a suppressor of Hedgehog signaling. Its inactivation might lead to a deregulation of the tumor promoting Hedgehog pathway in medulloblastoma. Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state. |
| Application Dilution | |
| WB | 1:300-5000 |
| ELISA | IHC-P1:200-400 |
| IHC-P | IFIHC-P1:50-200 |
| IHC-F | |
| IF | |
| ICC/IF | |
Frequently asked questions
Which applications is KCTD11 Polyclonal Antibody (bs-9637R) validated for, and at what dilution?
bs-9637R is validated for WB (1:300-5000); IHC-P (1:200-400); IF(IHC-P) (1:50-200). These are recommended starting dilutions; optimal dilutions should be determined by the end user.
Which species does KCTD11 Polyclonal Antibody (bs-9637R) react with?
Tested reactivity: Human, Mouse, Rat.
How should bs-9637R be stored?
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles. Storage buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
What immunogen was used to raise KCTD11 Polyclonal Antibody (bs-9637R)?
KLH conjugated synthetic peptide derived from human KCTD11 Immunogen range: 31-130/232.