INTS3 Polyclonal Antibody, Cy5.5 Conjugated
Applications
Reactivity
| Overview | |
| Catalog # | bs-9766R-Cy5.5 |
| Product Name | INTS3 Polyclonal Antibody, Cy5.5 Conjugated |
| Applications |
WB
IF
|
| Reactivity | Human, Mouse, Rat |
| Specifications | |
| Conjugation | Cy5.5 |
| Host | Rabbit |
| Source | KLH conjugated synthetic peptide derived from human INTS3 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target | |
| Gene ID | 65123 |
| Swiss Prot | Q68E01 |
| Subcellular location | Nucleus |
| Synonyms | INT3; SOSSA; SOSS-A; C1orf60; C1orf193; Integrator complex subunit 3; SOSS complex subunit A; Sensor of single-strand DNA complex subunit A; Sensor of ssDNA subunit A; INTS3 |
| Background | Component of the Integrator complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites. |
| Application Dilution | |
| WB | 1:300-5000 |
| IF | IHC-P1:50-200 |
Frequently asked questions
Which applications is INTS3 Polyclonal Antibody, Cy5.5 Conjugated (BS-9766R-CY5-5) validated for, and at what dilution?
BS-9766R-CY5-5 is validated for WB (1:300-5000); IF(IHC-P) (1:50-200). These are recommended starting dilutions; optimal dilutions should be determined by the end user.
Which species does INTS3 Polyclonal Antibody, Cy5.5 Conjugated (BS-9766R-CY5-5) react with?
Tested reactivity: Human, Mouse, Rat.
How should BS-9766R-CY5-5 be stored?
Store at -20C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. Storage buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
What immunogen was used to raise INTS3 Polyclonal Antibody, Cy5.5 Conjugated (BS-9766R-CY5-5)?
KLH conjugated synthetic peptide derived from human INTS3
What are the excitation and emission wavelengths of the Cy5.5 conjugate (BS-9766R-CY5-5)?
Cy5.5 on BS-9766R-CY5-5: excitation / emission 675nm/694nm.