human CD274 (B7-H1, PD-L1)/APC
Applications
Reactivity
| Overview | |
| Catalog # | bsm-30139m-apc-100t |
| Product Name | human CD274 (B7-H1, PD-L1)/APC |
| Applications |
FCM
|
| Reactivity | Human |
| Specifications | |
| Conjugation | Unconjugated |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone # | 4C11 |
| Isotype | IgG2b/Kappa |
| Concentration | n/a |
| Purification | Affinity purified by Protein G |
| Storage Buffer | 0.01M PBS, 0.5%BSA, 0.02% Proclin300 |
| Storage Condition | Store at 2-8°C |
| Target | |
| Gene ID | 29126.0 |
| Swiss Prot | Q9NZQ7 |
| Synonyms | Programmed cell death 1 ligand 1; CD274; B7 H; B7 H1; B7 homolog 1; B7-H1; B7H; B7H1; CD 274; CD274 antigen; CD274 molecule; MGC142294; MGC142296; PD L1; PD1L1_HUMAN; PD1L1_Mouse; PDCD1 ligand 1; PDCD1L1; PDCD1LG1; PDL 1; PDL1; Programmed death ligand 1; RGD1566211. |
| Background | This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] |
| Application Dilution | |
| FCM | 10ul/10^6 cells in 100ul |
Frequently asked questions
Which applications is human CD274 (B7-H1, PD-L1)/APC (bsm-30139M-APC) validated for, and at what dilution?
bsm-30139M-APC is validated for 10ul/10^6 cells in 100ul.
Which species does human CD274 (B7-H1, PD-L1)/APC (bsm-30139M-APC) react with?
Tested reactivity: Human.
How should bsm-30139M-APC be stored?
Store at 2-8°C Storage buffer: 0.01M PBS, 0.5%BSA, 0.02% Proclin300