AMACR Monoclonal Antibody, Biotin Conjugated
Applications
Reactivity
Predicted Reactivity
| Overview | |
| Catalog # | bsm-33053M-Biotin-100uL |
| Product Name | AMACR Monoclonal Antibody, Biotin Conjugated |
| Applications |
WB
|
| Reactivity | Human, Mouse |
| Predicted Reactivity | Rat |
| Specifications | |
| Conjugation | Biotin |
| Host | Mouse |
| Source | KLH conjugated synthetic peptide derived from human AMACR |
| Clonality | Monoclonal |
| Clone # | 6B3 |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein G. |
| Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20C for 12 months. |
| Target | |
| Gene ID | 23600 |
| Swiss Prot | Q9UHK6 |
| Synonyms | 2 arylpropionyl CoA epimerase; 2 methylacyl CoA racemase; 2-methylacyl-CoA racemase; Alpha methylacyl-CoA racemase deficiency, included; Alpha-methylacyl-CoA racemase; alpha-methylacyl-CoA racemase isoform 1; P504S; Amacr; AMACR; AMACR deficiency, included; CBAS4; P504S; RACE; 2 arylpropionyl CoA epimerase; Alpha methylacyl Coenzyme A racemase; Alpha methylacyl CoA racemase; AMACR_HUMAN; EC 5.1.99.4; Da1-8; RACE; RM; Macr 1; Macr1; Methylacyl CoA racemase alpha. |
| Background | alpha-methylacyl-CoA racemase(AMACR/P504S) is Prostate-specific antigen (PSA) screening for prostate cancer is now widespread in the United States among men of all ages. However PSA has limited specificity because benign disease, including prostatic enlargement and inflammation, can increase PSA levels. Thus, a more specific prostate cancer markers is needed. One such potential marker is AMACR, an enzyme that is involved in peroxisomal beta-oxidation of dietary branched-chain fatty acids. Recent studies have shown that, compared with expression in normal or benign prostate epithelium, AMACR is consistently overexpressed in prostate cancer epithelium, making it a specific marker for cancer cells within the prostate gland. Furthermore, overexpression of AMACR may increase the risk of prostate cancer because its expression is increased in premalignant lesions (prostatic intraepithelial neoplasia). |
| Application Dilution | |
| WB | 1:300-5000 |
Frequently asked questions
Which applications is AMACR Monoclonal Antibody, Biotin Conjugated (bsm-33053M-Biotin) validated for, and at what dilution?
bsm-33053M-Biotin is validated for WB (1:300-5000). These are recommended starting dilutions; optimal dilutions should be determined by the end user.
Which species does AMACR Monoclonal Antibody, Biotin Conjugated (bsm-33053M-Biotin) react with?
Tested reactivity: Human, Mouse. Predicted reactivity (expected from sequence homology but not yet tested): Rat.
How should bsm-33053M-Biotin be stored?
Store at -20C for 12 months. Storage buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
What immunogen was used to raise AMACR Monoclonal Antibody, Biotin Conjugated (bsm-33053M-Biotin)?
KLH conjugated synthetic peptide derived from human AMACR