Overview |
bsm-51242M |
VRK1 (5C1) Monoclonal Antibody |
WB |
Human |
Specifications |
Unconjugated |
Mouse |
Purified His-tagged VRK1 protein was used to produced this monoclonal antibody. |
Monoclonal |
5C1 |
IgG1 |
0.5ug/ul |
Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
Store at -20°C for 12 months. |
Target |
7443 |
Q99986 |
PCH1; PCH1A; Serine/threonine-protein kinase VRK1; Vaccinia-related kinase 1; VRK1 |
Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity. |
Application Dilution |
WB |
1:300-5000 |