| Overview |
| bsm-51345M |
| FZR (1C7) Monoclonal Antibody |
| WB, IF |
| Human |
| Specifications |
| Unconjugated |
| Mouse |
| This FZR antibody is generated from a mouse immunized with a recombinant protein between1-496 amino acids from human FZR. |
| Monoclonal |
| 1C7 |
| IgG1 |
| 0.5ug/ul |
| Purified by Protein G. |
| 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Store at -20°C for 12 months. |
| Target |
| 51343 |
| Q9UM11 |
| FZR; CDH1; FZR2; HCDH; HCDH1; CDC20C; Fizzy-related protein homolog; CDC20-like protein 1; Cdh1/Hct1 homolog; FZR1; FYR; KIAA1242 |
| Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. |
| Application Dilution |
| WB |
1:300-5000 |
| IF |
|
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