| Overview |
| bsm-51404M |
| USP5 (13C4) Monoclonal Antibody |
| WB |
| Human, Mouse, Rat |
| Specifications |
| Unconjugated |
| Mouse |
| This USP5 antibody is generated from a mouse immunized with a recombination protein from the human region of human USP5. |
| Monoclonal |
| 13C4 |
| IgG1 |
| 0.5ug/ul |
| Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Store at -20°C for 12 months. |
| Target |
| 8078 |
| P45974 |
| ISOT; Ubiquitin carboxyl-terminal hydrolase 5; Deubiquitinating enzyme 5; Isopeptidase T; Ubiquitin thioesterase 5; Ubiquitin-specific-processing protease 5; USP5; USP 5; USP-5 |
| Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition. |
| Application Dilution |
| WB |
1:300-5000 |
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