| Overview |
| bsm-51636M |
| USP2 Monoclonal Antibody |
| WB |
| Human, African Green Monkey |
| Specifications |
| Unconjugated |
| Mouse |
| Recombinant human USP2 between 1-258 amino acids. |
| Monoclonal |
| 1738CT331.50.87 |
| IgG1 _ |
| 0.5ug/ul |
| Purified by Protein G. |
| 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Target |
| 9099 |
| O75604 |
| Cytoplasm, Nucleus |
| Ubiquitin carboxyl-terminal hydrolase 2, 3.4.19.12, 41 kDa ubiquitin-specific protease, Deubiquitinating enzyme 2, Ubiquitin thioesterase 2, Ubiquitin-specific-processing protease 2, USP2, UBP41 |
This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
|
| Application Dilution |
| WB |
=1:500-2000， |
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