Dnmt3a Monoclonal Antibody
Applications
Reactivity
| Overview | |
| Catalog # | bsm-51677m |
| Product Name | Dnmt3a Monoclonal Antibody |
| Applications |
WB
|
| Reactivity | Human |
| Specifications | |
| Conjugation | Unconjugated |
| Host | Mouse |
| Source | Recombinant human Dnmt3a. |
| Clonality | Monoclonal |
| Clone # | G8L1 |
| Concentration | Lot Dependent |
| Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Target | |
| Gene ID | 1788 |
| Swiss Prot | Q9Y6K1 |
| Subcellular location | Cytoplasm, Nucleus |
| Synonyms | DNA (cytosine 5 ) methyltransferase 3 alpha; DNA (cytosine 5) methyltransferase 3A; DNA cytosine methyltransferase 3A2; DNA methyltransferase 3a; DNA methyltransferase HsaIIIA; DNA MTase HsaI; DNA MTase HsaIIIA; DNMT 3a; DNMT; DNMT3A2; M HsaIIIA; M.HsaIIIA; MCMT; Methyl CpG binding domain protein 3a. |
| Background | Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity. |
| Application Dilution | |
| WB | =1:500-4000 |
Frequently asked questions
Which applications is Dnmt3a Monoclonal Antibody (bsm-51677M) validated for, and at what dilution?
bsm-51677M is validated for WB (WB=1:500-4000). These are recommended starting dilutions; optimal dilutions should be determined by the end user.
Which species does Dnmt3a Monoclonal Antibody (bsm-51677M) react with?
Tested reactivity: Human.
How should bsm-51677M be stored?
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. Storage buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
What immunogen was used to raise Dnmt3a Monoclonal Antibody (bsm-51677M)?
Recombinant human Dnmt3a.