| Overview |
| bsm-51723M |
| XRN1 Monoclonal Antibody |
| WB |
| Human |
| Mouse |
| Specifications |
| Unconjugated |
| Mouse |
| Recombinant human XRN1 between1455-1706 amino acids. |
| Monoclonal |
| F12D4 |
| IgG1 _ |
| 0.5ug/ul |
| Purified by Protein G. |
| 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Target |
| 54464 |
| Q8IZH2 |
| Nucleus |
| XRN1_HUMAN; Dhm2; mXRN1; SEP1; Strand-exchange protein 1 homolog; 5'-3' exoribonuclease 1. |
| Lamins are type V intermediate filament proteins and are grouped into constitutively expressed B-type lamins and developmentally regulated A-type lamins. Lamin-binding proteins in the nuclear lamina and the nuclear interior include several protein families and/or types of proteins in higher eukaryotes such as the inner nuclear membrane proteins, lamin B receptor, emerin, MANI, three isoforms of lamina-associated polypeptide 1 (LAP 1), and several isoforms of LAP 2. Up to six LAP 2 isoforms derive from a single gene by alternative splicing in mammals and various isoforms have been described in Xenopus. The best characterized LAP2 isoforms are the inner nuclear membrane protein LAP 2 beta and the nucleoplasmic protein LAP 2 alpha, which are identical in their N-terminal 187-amino acid constant region but differ in their C termini. LAP 2 alpha specifically interacts with A-type lamins within the nuclear interior as part of a detergent- and salt-resistant nucleoskeletal structure. |
| Application Dilution |
| WB |
=1:500-2000， |
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