Cyclin E1 (4H7) Monoclonal Antibody

Applications

  • IHC-P
  • IF(ICC)

Reactivity

  • Human
  • Mouse
Overview
Catalog # bsm-52048R
Product Name Cyclin E1 (4H7) Monoclonal Antibody
Applications IHC-P, IF(ICC)
Reactivity Human, Mouse
Specifications
Conjugation Unconjugated
Host Rabbit
Source Synthetic peptide derive from human cyclin e1
Immunogen Range 361-410/410
Clonality Monoclonal
Clone # 4H7
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide.
Storage Condition Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Target
Gene ID 898
Swiss Prot P24864
Synonyms Cyclin E1 phospho T77; p-Cyclin E1 phospho T77; Cyclin E1 Thr77; CCNE 1; CCNE;CCNE1;Cyclin E1 antibody Cyclin Es;Cyclin Et;CyclinE; G1/S specic cyclin E.
Background Cyclin E is a regulatory subunit of Cdk2 and controls G1 / S transition during the mammalian cell cycle. Multiple isoforms of Cyclin E are only expressed in tumors but not in normal tissue, suggesting a post transcriptional regulation of Cyclin E. In vitro analyses indicated that these truncated variant isoforms of Cyclin E are able to phosphorylate histone H1. Alterations in the Cyclin E protein have been implicated as indicators of worse prognosis in various cancers.
Application Dilution
IHC-P 1:100-500
IF(ICC) 1:50