| Overview |
| bsm-52156r-pbs-only-100l |
| FOXO3a (Ser253) Monoclonal Antibody, PBS Only Conjugated |
| WB, IHC-F, IF, IHC-P |
| Human, Mouse, Rat |
| Specifications |
| PBS Only |
| Rabbit |
| Synthetic peptide derived from human FOXO3a(S253), around 230-280aa (phospho S253). |
| S253 |
| Monoclonal |
| 25B3 |
| IgG |
| Lot Dependent |
| Purified by Protein A. |
| PBS (pH=7.4) |
| Store at 4°C for 12 months. |
| Target |
| 2309 |
| O43524 |
| FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2; Forkhead box protein O3; AF6q21 protein; Forkhead in rhabdomyosarcoma-like 1; FOXO3 |
| Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation. |
| Application Dilution |
| WB |
1:200-800 |
| IHC-F |
1:200-800 |
| IF |
1:500-2000 |
| IHC-P |
1:200-800 |
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