STAT3 (p-Y705) Recombinant Antibody, APC Conjugated
Applications
Reactivity
| Overview | |
| Catalog # | bsm-52211r-apc-100ul |
| Product Name | STAT3 (p-Y705) Recombinant Antibody, APC Conjugated |
| Applications |
WB
IF
|
| Reactivity | Human, Mouse, Rat |
| Specifications | |
| Conjugation | APC |
| Host | Rabbit |
| Source | A synthesized peptide derived from human STAT3 around the phosphorylation site of Y705 |
| Clonality | Recombinant |
| Isotype | IgG |
| Concentration | 1mg/ml |
| Purification | purified by Protein A. |
| Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target | |
| Gene ID | 6774 |
| Swiss Prot | P40763 |
| Subcellular location | Cytoplasm, Nucleus |
| Synonyms | ADMIO; ADMIO1; APRF; HIES; 1110034C02Rik; STAT3_HUMAN; STAT3; Acute-phase response factor; STAT3_MOUSE; STAT3_RAT; signal transducer and activator of transcription 3; signal transducer and activator of transcription 3 (acute-phase response factor); STAT3 (phospho-Y705); p-STAT3; phospho-STAT3; STAT3 (phospho-Tyr705) |
| Background | Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity). |
| Application Dilution | |
| WB | 1:500-2000 |
| IF | 1:200-800 |