| Overview |
| bsm-52543r-apc-cy7-100ul |
| TCF7L2 Recombinant Antibody, APC-Cy7 Conjugated |
| WB, FCM, IF(IHC-P), IF(ICC) |
| Human, Mouse, Rat |
| Specifications |
| APC-Cy7 |
| Rabbit |
| Human TCF7L2 aa 1-100 |
| Recombinant |
| IgG |
| Lot Dependent |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 6934 |
| Q9NQB0 |
| Transcription factor 7-like 2, HMG box transcription factor 4, T-cell-specific transcription factor 4, T-cell factor 4, TCF-4, hTCF-4, TCF7L2 |
| Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. |
| Application Dilution |
| WB |
1:500-2000 |
| FCM |
FCM1:50-100 |
| IF(IHC-P) |
IFIHC-P1:50-200 |
| IF(ICC) |
IFICC1:50-200 |
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