| Overview |
| bsm-52809r-pbs-only-100l |
| RAGE Recombinant Antibody, PBS Only Conjugated |
| WB, IHC-F, IF, IHC-P |
| Human, Mouse, Rat |
| Specifications |
| PBS Only |
| Rabbit |
| Human RAGE between 1 to 350 amino acids |
| Recombinant |
| IgG |
| 1mg/ml |
| Purified by Protein A. |
| PBS (pH=7.4) |
| Store at 4°C for 12 months. |
| Target |
| 177 |
| Q15109 |
| Advanced glycosylation end product-specific receptor, Receptor for advanced glycosylation end products, AGER |
| Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides. |
| Application Dilution |
| WB |
1:200-1000 |
| IHC-F |
1:200-1000 |
| IF |
1:1000-2000 |
| IHC-P |
1:200-1000 |
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