TET2 (6A1) Monoclonal Antibody

Applications

  • WB
  • IP

Reactivity

  • Human
  • Mouse
Overview
Catalog # bsm-53017M
Product Name TET2 (6A1) Monoclonal Antibody
Applications WB, IP
Reactivity Human, Mouse
Specifications
Conjugation Unconjugated
Host Mouse
Source Monoclonal antibody raised in mouse against a recombinant protein containing the N-terminal 300 amino acids of human TET2 (tet oncogene family member 2).
Clonality Monoclonal
Clone # 6A1
Isotype IgG1
Concentration 1ug/ul
Purification Protein G purified polyclonal antibody in PBS containing 0.05% azide
Storage Buffer PBS with 0.05% sodium azide.
Storage Condition Store at -20°C for 12 months.
Target
Gene ID 54790
Swiss Prot Q6N021
Synonyms Methylcytosine dioxygenase TET2, TET2, KIAA1546
Background Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.
Application Dilution
WB 1:300-5000
IP 1-2ug