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HDAC2 (7G5) Monoclonal Antibody

Applications

  • WB
  • ELISA
  • IF(ICC)
  • dot-blot
  • ChIP-seq

Reactivity

  • Human
Overview
Catalog # bsm-53026M
Product Name HDAC2 (7G5) Monoclonal Antibody
Applications WB, ELISA, IF(ICC), dot-blot, ChIP-seq
Reactivity Human
Specifications
Conjugation Unconjugated
Host Mouse
Source Monoclonal antibody raised in mouse against human HDAC2 (Histone deacetylase 2), using a KLH-conjugated synthetic peptide containing a sequence from the C-terminal region of the protein
Clonality Monoclonal
Clone # 7G5
Isotype IgG1
Concentration 2ug/ul
Purification Protein A purified monoclonal antibody in PBS containing 0.05% azide and 0.05% ProClin 300
Storage Buffer PBS with 0.05% sodium azide.
Storage Condition Store at -20°C for 12 months.
Target
Gene ID 3066
Swiss Prot Q92769
Synonyms HD2, RPD3, YAF1
Background Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.
Application Dilution
WB 1:300-5000
ELISA 1:500-1000
IF(ICC) 1:50-200
dot-blot
ChIP-seq