CFH Recombinant Antibody
Applications
Reactivity
| Overview | |
| Catalog # | bsm-54051r-100uL |
| Product Name | CFH Recombinant Antibody |
| Applications |
WB
|
| Reactivity | Human |
| Specifications | |
| Conjugation | Unconjugated |
| Host | Rabbit |
| Source | Full length protein |
| Clonality | Recombinant |
| Isotype | IgG |
| Concentration | Lot dependent |
| Purification | Purified by Protein A. |
| Storage Buffer | 0.01M TBS (pH 7.4), 1% BSA, 0.02% Proclin 300, and 50% Glycerol |
| Storage Condition | Shipped at 4°. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Target | |
| Gene ID | 3075 |
| Swiss Prot | P08603 |
| Subcellular location | Secreted |
| Synonyms | Complement factor H, H factor 1, CFH, HF, HF1, HF2 |
| Background | A glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self-markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed. |
| Application Dilution | |
| WB | 1:500-2000 |
Frequently asked questions
Which applications is CFH Recombinant Antibody (bsm-54051R) validated for, and at what dilution?
bsm-54051R is validated for WB(WB) (1:500-2000). These are recommended starting dilutions; optimal dilutions should be determined by the end user.
Which species does CFH Recombinant Antibody (bsm-54051R) react with?
Tested reactivity: Human.
How should bsm-54051R be stored?
Shipped at 4°. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. Storage buffer: 0.01M TBS (pH 7.4), 1% BSA, 0.02% Proclin 300, and 50% Glycerol
What immunogen was used to raise CFH Recombinant Antibody (bsm-54051R)?
Full length protein