Overview |
bsm-54104R |
MLKL (Ser345) (7G4) Monoclonal Antibody |
WB, IHC-P, IF(ICC) |
Mouse |
Specifications |
Unconjugated |
Rabbit |
Synthetic phospho-peptide corresponding to residues surrounding Ser345 of human MLKL |
Ser345 |
Monoclonal |
7G4 |
IgG |
1ug/ul |
Purified by Protein A. |
Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide. |
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
Target |
74568 |
Q9D2Y4 |
Phospho-MLKL (S345); pMLKL Ser345; Mixed lineage kinase domain-like protein, Mlkl |
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity. |
Application Dilution |
WB |
1:300-5000 |
IHC-P |
1:200-400 |
IF(ICC) |
1:50-200 |