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phospho-MLKL (Ser345) Recombinant Antibody

Lane 1: Mouse Spleen; Lane 2: Mouse Lung; Lane 3: Mouse Thymus; Probed with MLKL (Ser345) (7G4) Monoclonal Antibody (bsm-54104R) at 1:1000 overnight at 4\u00b0C followed by a conjugated secondary antibody for 60 minutes at 37\u00b0C.
Lane 1: Mouse Spleen; Lane 2: Mouse Lung; Lane 3: Mouse Thymus; Probed with MLKL (Ser345) (7G4) Monoclonal Antibody (bsm-54104R) at 1:1000 overnight at 4°C followed by a conjugated secondary antibody for 60 minutes at 37°C.

Applications

  • WB
  • IP

Reactivity

  • Mouse

Predicted Reactivity

  • Human
Overview
Catalog # bsm-54104r
Product Name phospho-MLKL (Ser345) Recombinant Antibody
Applications WB, IP
Reactivity Mouse
Predicted Reactivity Human
Specifications
Conjugation Unconjugated
Host Rabbit
Source Synthetic phospho-peptide corresponding to residues surrounding Ser345 of human MLKL
Modification Site Ser345
Clonality Recombinant
Isotype IgG
Concentration Lot dependent
Purification Purified by Protein A.
Storage Buffer 0.01M TBS (pH 7.4), 1% BSA, 0.02% Proclin 300, and 50% Glycerol
Storage Condition Shipped at 4°. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Target
Gene ID 74568
Swiss Prot Q9D2Y4
Synonyms Phospho-MLKL (S345); pMLKL Ser345; Mixed lineage kinase domain-like protein, Mlkl
Background Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.
Application Dilution
WB 1:300-5000
IP 1-2ug

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