TMEM173 (1B8) Monoclonal Antibody
Applications
Reactivity
| Overview | |
| Catalog # | bsm-54122R |
| Product Name | TMEM173 (1B8) Monoclonal Antibody |
| Applications |
WB
FCM
|
| Reactivity | Human |
| Specifications | |
| Conjugation | Unconjugated |
| Host | Rabbit |
| Source | Recombinant protein within human TMEM173 aa 200 to the C-terminus |
| Clonality | Monoclonal |
| Clone # | 1B8 |
| Isotype | IgG |
| Concentration | Lot Dependent |
| Purification | Purified by Protein A. |
| Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Target | |
| Gene ID | 340061 |
| Swiss Prot | Q86WV6 |
| Synonyms | Stimulator of interferon genes protein; Endoplasmic reticulum interferon stimulator; Mediator of IRF3 activation; Transmembrane protein 173; hSTING; ERIS; hMITA; TMEM173; ERIS; MITA; STING. |
| Background | Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. |
| Application Dilution | |
| WB | 1:300-5000 |
| FCM | 1:20-100 |