| Overview |
| bsm-54122R |
| TMEM173 (1B8) Monoclonal Antibody |
| WB, FCM |
| Human |
| Specifications |
| Unconjugated |
| Rabbit |
| Recombinant protein within human TMEM173 aa 200 to the C-terminus |
| Monoclonal |
| 1B8 |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide. |
| Store at 4C for up to 2 weeks. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Target |
| 340061 |
| Q86WV6 |
| Stimulator of interferon genes protein; Endoplasmic reticulum interferon stimulator; Mediator of IRF3 activation; Transmembrane protein 173; hSTING; ERIS; hMITA; TMEM173; ERIS; MITA; STING. |
| Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. |
| Application Dilution |
| WB |
1:300-5000 |
| FCM |
1:20-100 |
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