| Overview |
| bsm-54268R |
| RBPJ (1D4) Monoclonal Antibody |
| WB, IHC-P |
| Human |
| Specifications |
| Unconjugated |
| Rabbit |
| Recombinant protein within human RBPJK aa 1-200 |
| Monoclonal |
| 1D4 |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide. |
| Store at 4C for up to 2 weeks. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Target |
| 3516 |
| Q06330 |
| Cytoplasm, Nucleus |
| Recombining binding protein suppressor of hairless; CBF-1; J kappa-recombination signal-binding protein; RBP-J kappa; Renal carcinoma antigen NY-REN-30; RBP-J; RBP-JK; RBPJ; IGKJRB; IGKJRB1; RBPJK; RBPSUH |
| Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. |
| Application Dilution |
| WB |
1:300-5000 |
| IHC-P |
1:200-400 |
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