| Overview |
| bsm-54277r-bf350-100ul |
| Alpha Synuclein Recombinant Antibody, AbBy Fluor-350 Conjugated |
| WB, IF, Flow-Cyt |
| Human, Rat |
| Specifications |
| AbBy Fluor-350 |
| Rabbit |
| Recombinant full length Human protein |
| Monoclonal |
| 3H12 |
| IgG |
| 1mg/ml |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 6622 |
| P37840 |
| Cytoplasm, Nucleus, Secreted, Cell membrane |
| Alpha-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP; SNCA; NACP; PARK1; PARK4 |
| Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity |
| Application Dilution |
| WB |
1:1000-2000 |
| IF |
1:200-800 |
| Flow-Cyt |
1:50-200 |
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