Overview |
bsm-54283R |
Furin (8C3) Monoclonal Antibody |
WB, IHC-P |
Human, Mouse, Rat |
Specifications |
Unconjugated |
Rabbit |
Recombinant protein within human Furin aa 200-400. |
Monoclonal |
8C3 |
IgG |
1ug/ul |
Purified by Protein A. |
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
Target |
5045 |
P09958 |
Secreted, Cell membrane, Golgi apparatus, Endosome |
Dibasic-processing enzyme; Paired basic amino acid residue-cleaving enzyme; PACE; FURIN; FUR; PACE; PCSK3 |
Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif. Mediates processing of TGFB1, an essential step in TGF-beta-1 activation. Probably cleaves and activates anthrax and diphtheria toxins. Required for H7N1 and H5N1 influenza virus infection probably by cleaving hemagglutinin. |
Application Dilution |
WB |
1:500-1:1000 |
IHC-P |
IHC-P1:50-1:100 |