Arginase-1 (2C12) Monoclonal Antibody
Applications
Reactivity
| Overview | |
| Catalog # | bsm-54331R |
| Product Name | Arginase-1 (2C12) Monoclonal Antibody |
| Applications | WB, IHC-P |
| Reactivity | Human |
| Specifications | |
| Conjugation | Unconjugated |
| Host | Rabbit |
| Source | Recombinant protein within human Liver Arginase aa 100-300 |
| Clonality | Monoclonal |
| Clone # | 2C12 |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide. |
| Storage Condition | Store at 4C for up to 2 weeks. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Target | |
| Gene ID | 383 |
| Swiss Prot | P05089 |
| Subcellular location | Cytoplasm |
| Synonyms | Arginase-1; Liver Arginase; Type I arginase; ARG1 |
| Background | Arginase I which is expressed almost exclusively in the liver, catalyzes the conversion of arginine to ornithine and urea . The human arginase I gene, which maps to chromosome 6q23, encodes a 322 amino acid protein. Arginase I exists as a homotrimeric protein and contains a binuclear manganese cluster. Arginase II catalyzes the same reaction as arginase I, but differs in its tissue specificity and subcellular location. Specifically, arginase II localizes to the mitochondria. Arginase II is expressed in non-hepatic tissues, with the highest levels of expression in the kidneys, but, unlike arginase I, is not expressed in liver. The human arginase II gene, which maps to chromosome 14q24.1-q24.3, encodes a 354 amino acid protein. In addition, arginase II contains a putative amino-terminal mitochondrial localization sequence. |
| Application Dilution | |
| WB | 1:300-5000 |
| IHC-P | 1:200-400 |
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