PICK1 Recombinant Antibody
Applications
Reactivity
Predicted Reactivity
| Overview | |
| Catalog # | bsm-54393r-100uL |
| Product Name | PICK1 Recombinant Antibody |
| Applications |
WB
FCM
IP
|
| Reactivity | Human |
| Predicted Reactivity | Mouse, Rat |
| Specifications | |
| Conjugation | Unconjugated |
| Host | Rabbit |
| Source | Recombinant protein within N-terminal human PICK1. |
| Clonality | Recombinant |
| Isotype | IgG |
| Concentration | Lot Dependent |
| Purification | Purified by Protein A. |
| Storage Buffer | 0.01M TBS (pH 7.4), 1% BSA, 0.02% Proclin 300, and 50% Glycerol |
| Storage Condition | Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles. |
| Target | |
| Gene ID | 9463 |
| Swiss Prot | Q9NRD5 |
| Subcellular location | Cell membrane, Cytoskeleton |
| Synonyms | PRKCA-binding protein; Protein interacting with C kinase 1; protein interacting with PRKCA 1; Protein kinase C-alpha-binding protein; PICK1; PRKCABP |
| Background | Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function. |
| Application Dilution | |
| WB | 1:300-5000 |
| FCM | 1:20-100 |
| IP | 1-2ug |
Frequently asked questions
Which applications is PICK1 Recombinant Antibody (bsm-54393R) validated for, and at what dilution?
bsm-54393R is validated for WB (1:300-5000); FCM (1:20-100); IP (1-2ug). These are recommended starting dilutions; optimal dilutions should be determined by the end user.
Which species does PICK1 Recombinant Antibody (bsm-54393R) react with?
Tested reactivity: Human. Predicted reactivity (expected from sequence homology but not yet tested): Mouse, Rat.
How should bsm-54393R be stored?
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles. Storage buffer: 0.01M TBS (pH 7.4), 1% BSA, 0.02% Proclin 300, and 50% Glycerol
What immunogen was used to raise PICK1 Recombinant Antibody (bsm-54393R)?
Recombinant protein within N-terminal human PICK1.