Overview |
bsm-54437R |
Lysyl-tRNA synthetase (1H8) Monoclonal Antibody |
WB, IHC-P, IP |
Human, Mouse, Rat |
Specifications |
Unconjugated |
Rabbit |
Recombinant protein corresponding to C-terminal human Lysyl tRNA synthetase. |
Monoclonal |
1H8 |
IgG |
1ug/ul |
Purified by Protein A. |
Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide. |
Store at -20°C for 12 months. |
Target |
3735 |
Q15046 |
Cytoplasm, Nucleus, Secreted, Mitochondrion, Cell membrane |
Lysine tRNA ligase; Lysyl tRNA synthetase; LysRS; KARS; KIAA0070 |
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity. |
Application Dilution |
WB |
1:300-5000 |
IHC-P |
1:200-400 |
IP |
1-2ug |