Overview |
bsm-54563R |
Phospho-c-Myc(T58) Monoclonal Antibody |
WB, FCM, IF(ICC) |
Human |
Specifications |
Unconjugated |
Rabbit |
Recombinant protein |
Thr58 |
Monoclonal |
60D10
|
IgG |
1ug/ul |
Purified by Protein A. |
Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide. |
Store at -20°C for 12 months. |
Target |
4609 |
P01106 |
Nucleus |
Avian myelocytomatosis viral oncogene homolog antibody, bHLHe39 antibody, c Myc antibody, Class E basic helix-loop-helix protein 39 antibody, MRTL antibody, Myc antibody, Myc protein antibody, Myc proto oncogene protein antibody, Myc proto-oncogene protein antibody, myc related translation/localization regulatory factor antibody, MYC_HUMAN antibody, Myc2 antibody, MYCC antibody, Niard antibody, Nird antibody, Proto-oncogene c-Myc antibody, Transcription factor p64 antibody, v myc avian myelocytomatosis viral oncogene homolog antibody, v myc myelocytomatosis viral oncogene homolog antibody |
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]. |
Application Dilution |
WB |
1:300-5000 |
FCM |
1:20-100 |
IF(ICC) |
1:50-200 |