Phospho-c-Myc(T58) Monoclonal Antibody

Applications

  • WB
  • FCM
  • IF(ICC)

Reactivity

  • Human
Overview
Catalog # bsm-54563R
Product Name Phospho-c-Myc(T58) Monoclonal Antibody
Applications WB, FCM, IF(ICC)
Reactivity Human
Specifications
Conjugation Unconjugated
Host Rabbit
Source Recombinant protein
Modification Site Thr58
Clonality Monoclonal
Clone # 60D10
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide.
Storage Condition Store at -20°C for 12 months.
Target
Gene ID 4609
Swiss Prot P01106
Subcellular location Nucleus
Synonyms Avian myelocytomatosis viral oncogene homolog antibody, bHLHe39 antibody, c Myc antibody, Class E basic helix-loop-helix protein 39 antibody, MRTL antibody, Myc antibody, Myc protein antibody, Myc proto oncogene protein antibody, Myc proto-oncogene protein antibody, myc related translation/localization regulatory factor antibody, MYC_HUMAN antibody, Myc2 antibody, MYCC antibody, Niard antibody, Nird antibody, Proto-oncogene c-Myc antibody, Transcription factor p64 antibody, v myc avian myelocytomatosis viral oncogene homolog antibody, v myc myelocytomatosis viral oncogene homolog antibody
Background The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008].
Application Dilution
WB 1:300-5000
FCM 1:20-100
IF(ICC) 1:50-200