FRATAXIN (2G1) Monoclonal Antibody

$Lane 1: K562; Lane 2: Jurkat; Lane 3: Raji; Lane 4: DU145; Lane 5: mouse kidney; Lane 6: mouse liver; Lane 7: mouse heart lysates, probed with FRATAXIN (2G1) Monoclonal Antibody, Unconjugated (bsm-58001R) at 1:1000 dilution and 4\u02daC overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37\u02daC.$

Lane 1: K562; Lane 2: Jurkat; Lane 3: Raji; Lane 4: DU145; Lane 5: mouse kidney; Lane 6: mouse liver; Lane 7: mouse heart lysates, probed with FRATAXIN (2G1) Monoclonal Antibody, Unconjugated (bsm-58001R) at 1:1000 dilution and 4\u02daC overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37\u02daC.

Applications

Reactivity

Human

Overview
Catalog #	bsm-58001R
Product Name	FRATAXIN (2G1) Monoclonal Antibody
Applications	WB
Reactivity	Human
Specifications
Conjugation	Unconjugated
Host	Rabbit
Source	Full length recombinant human Frataxin protein
Clonality	Monoclonal
Clone #	2G1
Isotype	IgG
Concentration	Not Determined
Purification	Purified by Protein A.
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage Condition	Store at -20°C for 12 months.
Target
Gene ID	2395
Swiss Prot	Q16595
Synonyms	Frataxin, mitochondrial; FXN; Friedreich ataxia protein; FRDA; X25
Background	Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe2+ to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe2+ to Fe3+; the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown using heterologous overexpression systems. Modulates the RNA-binding activity of ACO1.
Application Dilution
WB	1:300-5000