PD-L1 (6C8) Monoclonal Antibody
Applications
Reactivity
| Overview | |
| Catalog # | bsm-58003R-100uL |
| Product Name | PD-L1 (6C8) Monoclonal Antibody |
| Applications |
WB
FCM
|
| Reactivity | Human |
| Specifications | |
| Conjugation | Unconjugated |
| Host | Rabbit |
| Source | Recombinant human PD-L1 extracellular domain |
| Clonality | Monoclonal |
| Clone # | 6C8 |
| Isotype | IgG |
| Concentration | Lot Dependent |
| Purification | purified by Protein A. |
| Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20°C for 12 months. |
| Target | |
| Gene ID | 29126 |
| Swiss Prot | Q9NZQ7 |
| Synonyms | Programmed cell death 1 ligand 1; CD274; B7H1; PDCD1L1; PDCD1LG1; PDL1; Programmed death ligand 1 |
| Background | Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/CD279, modulates the activation threshold of T-cells and limits T-cell effector response (PubMed:11015443). The PDCD1/CD279-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:28813417, PubMed:28813410). Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (PubMed:10581077). |
| Application Dilution | |
| WB | 1:300-5000 |
| FCM | 1:20-100 |
Frequently asked questions
Which applications is PD-L1 (6C8) Monoclonal Antibody (bsm-58003R) validated for, and at what dilution?
bsm-58003R is validated for WB (1:300-5000); FCM (1:20-100). These are recommended starting dilutions; optimal dilutions should be determined by the end user.
Which species does PD-L1 (6C8) Monoclonal Antibody (bsm-58003R) react with?
Tested reactivity: Human.
How should bsm-58003R be stored?
Store at -20°C for 12 months. Storage buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
What immunogen was used to raise PD-L1 (6C8) Monoclonal Antibody (bsm-58003R)?
Recombinant human PD-L1 extracellular domain