| Overview |
| bsm-62280r-biotin-100ul |
| PA26 Recombinant Antibody, Biotin Conjugated |
| WB |
| Human, Mouse, Rat |
| Specifications |
| Biotin |
| Rabbit |
| KLH conjugated synthetic peptide derived from human Sestrin 1 |
| Recombinant |
| IgG |
| Lot dependent |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Store at -20°C for 12 months. |
| Target |
| 27244 |
| Q9Y6P5 |
| Nucleus |
| PA26; sesn1; SEST1; sestrin 1. |
| Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. |
| Application Dilution |
| WB |
1:300-5000 |
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