| Overview |
| bsm-62786r-biotin-100ul |
| HTRA1 Recombinant Antibody, Biotin Conjugated |
| WB |
| Human |
| Specifications |
| Biotin |
| Rabbit |
| KLH conjugated synthetic peptide derived from human Serine protease HTRA1 |
| Recombinant |
| IgG |
| Lot dependent |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Store at -20°C for 12 months. |
| Target |
| 5654 |
| Q92743 |
| Secreted |
| ARMD7; CARASIL; High-temperature requirement A serine peptidase 1; HtrA; HtrA serine peptidase 1; HTRA1; IGFBP5 protease; ORF480; Protease serine 11 (IGF binding); protease serine 11; PRSS11; Serine protease 11; Serine protease HTRA1. |
| Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. |
| Application Dilution |
| WB |
1:300-5000 |
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