Lamin A/C Antibody
Applications
Reactivity
| Overview | |
| Catalog # | bsm-70138M |
| Product Name | Lamin A/C Antibody |
| Applications |
WB
IHC
|
| Specificity | Specific for endogenous levels of the ~64 kDa and ~74 kDa lamin A and C proteins. |
| Reactivity | Human |
| Specifications | |
| Conjugation | Unconjugated |
| Host | Mouse |
| Source | Recombinant full length human lamin C expressed in and purified from E. Coli. |
| Clonality | Monoclonal |
| Clone # | 4C4 |
| Isotype | IgG1 |
| Concentration | Lot Dependent |
| Purification | Purified by Protein G. |
| Storage Buffer | PBS + 10 mM NaN3. |
| Storage Condition | Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cy |
| Target | |
| Gene ID | 4000 |
| Swiss Prot | P02545 |
| Synonyms | 70 kDa lamin antibody, Cardiomyopathy dilated 1A (autosomal dominant) antibody, CDCD1 antibody, CDDC antibody, CMD1A antibody, CMT2B1 antibody, EMD2 antibody, FPL antibody, FPLD antibody, FPLD2 antibody, HGPS antibody, IDC antibody, Lamin A antibody, Lamin A/C antibody, Lamin A/C like 1 antibody, Lamin antibody, Lamin C antibody, Lamin-A/C antibody, LDP1 antibody, LFP antibody, LGMD1B antibody, Limb girdle muscular dystrophy 1B (autosomal dominant) antibody, LMN 1 antibody, LMN A antibody, LMN C antibody, LMN1 antibody, LMNA antibody, LMNA_HUMAN antibody, LMNC antibody, LMNL1 antibody, Prelamin A/C antibody, PRO1 antibody, Renal carcinoma antigen NY REN 32 antibody, Renal carcinoma antigen NY-REN-32 antibody, Renal carcinoma antigen NYREN32 antibody |
| Background | Lamins A and C are nuclear structural proteins that are part of the intermediate filament family and coded for by the same gene (LMNA). Lamins A and C are nearly identical except for their carboxy termini (McKeon et al., 1986). Mutations in the gene encoding lamins A/C have been shown to cause a variety of diseases including autosomal dominant Emery-Dreifuss muscular dystrophy (Bonne et al., 1995), autosomal dominant limbgirdle muscular dystrophy (Muchir et al., 2000) and Charcot-Marie-Tooth disorder type 2 (De Sandre-Giavonnoli et al., 2002). |
| Application Dilution | |
| WB | 1:300-5000 |
| IHC | |