Retinoic Acid Receptor, -Isotype Antibody

Applications

Reactivity

Human
Rat

Predicted Reactivity

Mouse
Dog
Guinea Pig
Non-Human Primate

Overview
Catalog #	bsm-70245m
Product Name	Retinoic Acid Receptor, -Isotype Antibody
Applications	WB
Specificity	Specific for endogenous levels of the ~48 kDa RAR- isotype. The antigen is identical in both _1 and _2 isoforms.
Reactivity	Human, Rat
Predicted Reactivity	Mouse, Dog, Guinea Pig, Non-Human Primate
Specifications
Conjugation	Unconjugated
Host	Mouse
Source	Synthetic peptide corresponding to amino acid residues from the N-terminal region of human Retinoic Acid Receptor, -Isotype, conjugated to keyhole limpet hemocyanin (KLH).
Clonality	Monoclonal
Clone #	336
Isotype	IgG1
Concentration	Lot dependent
Purification	Purified by Protein G.
Storage Buffer	10 mM HEPES (pH 7.5), 150 mM NaCl, 100 g per ml BSA and 50% glycerol.
Storage Condition	Storage at -20C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20C.
Target
Gene ID	5915
Swiss Prot	P10826
Synonyms	HAP antibody, HBV-activated protein antibody, NR1B2 antibody, Nuclear receptor subfamily 1 group B member 2 antibody, RAR B antibody, RAR beta antibody, RAR epsilon antibody, RAR-beta antibody, RAR-epsilon antibody, RARB antibody, RARB_HUMAN antibody, Retinoic acid receptor beta 2 antibody, Retinoic acid receptor beta 4 antibody, Retinoic acid receptor beta 5 antibody, Retinoic acid receptor beta antibody, Retinoic acid receptor beta polypeptide antibody, RRB2 antibody
Background	Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The Retinoid X receptors (RXRs) family (RXR_, _ and _) preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors (RARs). RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005).
Application Dilution
WB