Retinoic Acid Receptor, -Isotype Antibody
Applications
Reactivity
Predicted Reactivity
| Overview | |
| Catalog # | bsm-70245m |
| Product Name | Retinoic Acid Receptor, -Isotype Antibody |
| Applications |
WB
|
| Specificity | Specific for endogenous levels of the ~48 kDa RAR-ß isotype. The antigen is identical in both β1 and β2 isoforms. |
| Reactivity | Human, Rat |
| Predicted Reactivity | Mouse, Dog, Guinea Pig, Non-Human Primate |
| Specifications | |
| Conjugation | Unconjugated |
| Host | Mouse |
| Source | Synthetic peptide corresponding to amino acid residues from the N-terminal region of human Retinoic Acid Receptor, ß-Isotype, conjugated to keyhole limpet hemocyanin (KLH). |
| Clonality | Monoclonal |
| Clone # | 336 |
| Isotype | IgG1 |
| Concentration | Lot dependent |
| Purification | Purified by Protein G. |
| Storage Buffer | 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. |
| Storage Condition | Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C. |
| Target | |
| Gene ID | 5915 |
| Swiss Prot | P10826 |
| Synonyms | HAP antibody, HBV-activated protein antibody, NR1B2 antibody, Nuclear receptor subfamily 1 group B member 2 antibody, RAR B antibody, RAR beta antibody, RAR epsilon antibody, RAR-beta antibody, RAR-epsilon antibody, RARB antibody, RARB_HUMAN antibody, Retinoic acid receptor beta 2 antibody, Retinoic acid receptor beta 4 antibody, Retinoic acid receptor beta 5 antibody, Retinoic acid receptor beta antibody, Retinoic acid receptor beta polypeptide antibody, RRB2 antibody |
| Background | Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The Retinoid X receptors (RXRs) family (RXRα, β and γ) preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors (RARs). RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005). |
| Application Dilution | |
| WB | |