| Overview |
| bsm-70614m |
| PKC_ (N-terminal region) Antibody |
| WB |
| This antibody detects a 78 kDa* protein corresponding to the molecular mass of PKC_ on SDS-PAGE immunoblots of adult mouse brain tissue lysate. This sequence is conserved in rat and mouse PKC_, and has low homology to other PKC family members. |
| Human, Mouse, Rat |
| Specifications |
| Unconjugated |
| Mouse |
| Clone (M242) was generated from a recombinant human protein that included amino acids residues in the N-terminal region. |
| Monoclonal |
| M242 |
| IgG2b |
| Purified by Protein A. |
| PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
| Storage at -20C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20C. |
| Target |
| Q05655 |
| PKCdelta |
| The Protein Kinase C (PKC) family of homologous serine/threonine protein kinases is involved in a number of processes such as growth, differentiation, and cytokine secretion. At least eleven isozymes have been described. PKC consists of a single polypeptide chain containing four conserved regions (C) and five variable regions (V). The N-terminal half interacts with PKC activators Ca2+, phospholipid, diacylglycerol, or phorbol ester, while the C-terminal half contains the catalytic domain. The conventional PKC subfamily (_, _1, _II, and _) is regulated by both Ca2+ and diacylglycerol. The PKC pathway represents a major signal transduction system that is activated following ligand-stimulation of transmembrane receptors by hormones, neurotransmitters, and growth factors. The phosphorylation of multiple sites in PKCs regulates their activity. |
| Application Dilution |
| WB |
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