Ginkgolide A

Overview
Catalog #	bs-76370c-25mg
Product Name	Ginkgolide A
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 15291-75-5 Molecular formula: C20H24O9 Molecular weight: 408.4 Purity: >98% (HPLC) Appearance: White powder. Solubility: Soluble in DMSO (20mg/ml), DMF (20mg/ml) or ethanol (3mg/ml). InChiKey: FPUXKXIZEIDQKW-VKMVSBOZSA-N SMILES: O=C1[C@@H](C)[C@]([C@](O1)([H])C2)(O)[C@]([C@]32[C@H]4C[C@@H](C(C)(C)C)[C@]53[C@H]6O)(C(O4)=O)O[C@]5([H])OC6=O SMILES: [H][C@]12C[C@@]34[C@@]5([H])C[C@@H](C(C)(C)C)[C@@]33[C@@H](O)C(=O)O[C@@]3([H])O[C@@]4(C(=O)O5)[C@@]1(O)[C@H](C)C(=O)O2
Description	Ginkgolide A is a terpenoid lactone originally isolated from G. biloba leaves. It shows diverse biological activities, including antioxidant, neuroprotective, anti-inflammatory and antiproliferative effects. Ginkgolide A inhibits platelet activating factor (PAF)-dependent aggregation of human platelets. It inhibits nitric oxide (NO) production. It also shows anxiolytic-like activity. It Inhibits NF-kappa activity by NF-kappa-specific suppressor IkappaBalpha. Ginkgolide A is a ligand of pregnane X receptor (PXR). It showed hepatoprotective efficacy by inducing cellular lipoapoptosis and by inhibiting cellular inflammation in NAFLD. Ginkgolide A reduced the proliferation rate of OVCA429 ovarian cancer cells by 40%.