ZM-447439

Overview
Catalog #	bs-82024c-5mg
Product Name	ZM-447439
Specifications
Storage Buffer	White solid
Storage Condition	RT
Target
Product Information	ZM-447439 is a selective ATP-competitive inhibitor of Aurora kinase B1 (IC50 = 50 nM, Aur A IC50 = 1 µM, Aur C IC50 = 250 nM at physiological ATP concentrations2, Ref.1 lists Aur A IC50 = 110nM and Aur B IC50 = 113nM). It did not significantly inhibit a panel of 14 other kinases including mitotic kinases CDK1 and PLK1. It prevents chromosome alignment, spindle checkpoint function and cytokinesis.1,2
Description	CAS Number: 331771-20-1 Chemical Name: N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide Molecular weight: 513.59 Formula: C29H31N5O4 Solubility: DMSO (50 mg/ml) Ethanol (25 mg/ml) Physical Properties: White solid Purity: 98% by TLC [10% methanol in methylene chloride; Rf = 0.30]