JNK-IN-8

Overview
Catalog #	bs-83016c-5mg
Product Name	JNK-IN-8
Specifications
Storage Buffer	Pale yellow solid
Storage Condition	-20°C
Target
Product Information	JNK-IN-8 is a potent and selective irreversible JNK inhibitor (IC50s=4.67, 18.7 and 0.98 nM for JNK1, 2 and 3 respectively).1 JNK blockade with JNK-IN-8 overcomes PD-L1-mediated resistance to chemotherapy in colorectal cancer.2 Improves ARDS-induced cognitive impairment by inhibition of JNK/NF-kB-mediated NLRP3 inflammasome activation.3
Description	CAS Number: 1410880-22-6 Chemical Name: 3-[[4-(Dimethylamino)-1-oxo-2-buten-1-yl]amino]-N-[3-methyl-4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide Molecular weight: 507.6 Formula: C29H29N7O2 Solubility: DMSO (45 mg/ml) Physical Properties: Pale yellow solid Purity: >98% by HPLC NMR (Conforms)