OSS-128167

Overview
Catalog #	bs-83100c-5-mg
Product Name	OSS-128167
Specifications
Storage Buffer	Pink solid
Storage Condition	-20°C
Target
Product Information	OSS-128167 (887686-02-4) is an inhibitor of SIRT6 (IC50=89 µM) showing selectivity over SIRT1 and SIRT2 (IC50s=1,578 and 751 µM, respectively).1 In diffuse large B-cell lymphoma cells which overexpress SIRT6, treatment with OSS-128167 resulted in higher rates of apoptosis, arrested cell cycle progression and augmented sensitivity to chemotherapy.2 It exacerbates diabetic cardiomyopathy by aggravating inflammation and oxidative stress in a streptozotocin-induced diabetic mouse model3 and delays peripheral nerve recovery after injury by suppressing migration, phagocytosis and M2-polarization of macrophages4. OSS-128167 promotes cell senescence and aging in myocardial H9c2 cells.5
Description	CAS Number: 887686-02-4 Chemical Name: 5-(3-(Furan-2-carboxamido)benzamido)-2-hydroxybenzoic acid Molecular weight: 366.66 Formula: C19H14N2O6 Solubility: DMSO (25 mg/ml) Ethanol (25 mg/ml) Physical Properties: Off-white solid Purity: >98% by TLC NMR (Conforms)