RECTAS

Overview
Catalog #	bs-83108c-5-mg
Product Name	RECTAS
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	RECTAS, a pre-mRNA splice modulator (Rectifier of Aberrant Splicing), was discovered in a small molecule screen for compounds that rectify aberrant IKBKAP splicing in cells from patients with familial dysautonomia. RECTAS (2 mM) increased the expression of IKAP and restored tRNA modifications.1,2 It directly interacts with CDC-like kinases enhancing SRSF6 phosphorylation.2 A combination treatment with RECTAS and phenylbutyric acid was shown to restore DJ-1 protein and mitochondrial dysfunction in Parkinson’s disease models.3
Description	CAS Number: 101862-47-9 Chemical Name: 2-Chloro-N-(2-furanylmethyl)-9H-purin-6-amine Molecular weight: 249.66 Formula: C10H8ClN5O Solubility: DMSO (27 mg/ml) Physical Properties: Pale yellow solid Purity: >98% by TLC NMR (Conforms)