Locostatin
| Overview | |
| Catalog # | bs-83112c-5-mg |
| Product Name | Locostatin |
| Specifications | |
| Conjugation | Unconjugated |
| Storage Buffer | Off-white solid |
| Storage Condition | -20°C |
| Target | |
| Background | Inhibits cell migration by disrupting the interaction between Raf kinase inhibitor protein (RKIP) and Raf-1 kinase.1 Locostatin covalently binds to His86 of RKIP and also disrupts its interaction with G protein-coupled receptor kinase 2.2 Effectively inhibits cytokine release by human lymphocytes.3 Alleviates CCl4-induced liver fibrosis in a mouse model.4 A useful probe to explore the complex functions of RKIP in cell physiology.5 |
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