CID1067700
| Overview | |
| Catalog # | bs-83118c-5-mg |
| Product Name | CID1067700 |
| Specifications | |
| Conjugation | Unconjugated |
| Storage Buffer | beige solid |
| Storage Condition | -20°C |
| Target | |
| Background | A specific competitive inhibitor of nucleotide binding to Rab7, an endosome-localized small GTPase.1 It interferes with the Rab7-RILP interaction, locking the GTPase in an inactive conformation.2 Impairs B cell class switching and plasma cell survival dampening, the pathogenic autoantibody response in lupus.3 Inhibits the Arf-like small GTPase Arl8b, blocking cellular egress of b-coronaviruses (SARS-CoV-2) which utilize a lysosomal exocytosis pathway.4 |
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