Purvalanol A

Overview
Catalog #	bs-83340c-25mg
Product Name	Purvalanol A
Specifications
Storage Buffer	Pale green solid
Storage Condition	-20°C
Target
Product Information	Cyclin-dependent kinase inhibitor. IC50s= 4, 70, 35, 75 and 850 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk5/p35 and cdk4/cyclin D1 and respectively.1 Reversibly arrests synchronized cells in G1 and G2 phase.2 Induces ER stress-mediated apoptosis and autophagy in colon cancer cells.3 Suppresses Src-mediated transformation by inhibiting both CDKs and c-Src.4 In cells transformed with MYC, purvalanol A rapidly down-regulates survivin expression and induces MYC-dependent apoptosis.5 Cell permeable.
Description	CAS Number: 212844-53-6 Chemical Name: CDK inhibitor Molecular Weight: 388.89 Formula: C19H25ClN6O Solubility: DMSO (35 mg/ml) Physical Properties: Pale green solid Purity: 98% by HPLC, NMR (Conforms)