Nintedanib

Overview
Catalog #	bs-83353c-50mg
Product Name	Nintedanib
Specifications
Storage Buffer	Yellow solid
Storage Condition	-20°C
Target
Product Information	Nintedanib is a potent inhibitor of VEGFR, PDGFR, FGFR (IC50 = 13-34 nM for VEGFR, 59-65 nM for PDGFR and 37-108 nM for FGFR subtypes).1 Also inhibits Flt-3, Lck, Lyn and Src (IC50 = 16-156 nM). Inhibits VEGF-stimulated proliferation of HUVECs.1 Inhibits tumor growth in a mouse tumor xenograft model.1 A novel therapeutic agent for treatment of idiopathic pulmonary fibrosis.2,3 Alleviates chronic pancreatitis by inhibiting the activation of pancreatic stellate cells.4
Description	CAS Number: 656247-17-5 Chemical Name: VEGFR, PDGFR and FGFR kinase inhibitor Molecular Weight: 539.64 Formula: C31H33N5O4 Solubility: DMSO (4 mg/ml) Physical Properties: Yellow solid Purity: >98% by HPLC NMR (Conforms)