SAG

Overview
Catalog #	bs-83398c-5mg
Product Name	SAG
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	Smoothened agonist which bind directly to SMO and can block SMO inhibition by cyclopamine. The conformation of SMO is altered by SAG binding which results in the accumulation of SMO in cilia and activated gene transcription. It should be noted that SAG inhibits hedgehog signaling at concentrations greater than 1 µM (EC50 for SMO activation is ~ 3 nM).1
Description	CAS Number: 364590-63-6 Chemical Name: Smoothened agonist Molecular Weight: 490.07 Formula: C28H28ClN3OS Solubility: DMSO (20 mg/ml) Ethanol (20 mg/ml) DMF (20 mg/ml) Physical Properties: Off-white solid Purity: >98% by HPLC NMR (Conforms)