Vorasidenib

Overview
Catalog #	bs-83405c-25mg
Product Name	Vorasidenib
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Vorasidenib is a highly potent (IC50’s = 7 nM IDH2-R140Q, 0.6 nM IDH1-R132H/WT, and 0.25 nM Neurosphere TS603 IDH1-R132H), selective, and brain-penetrant inhibitor of mutant isocitrate dehydrogenase 1 and 2 (IDH1/2).1 It led to >97% inhibition of 2-hydroxyglutarate production in mIDH1 glioma tissue. Vorasidenib significantly improved progression-free survival and delayed time to next intervention in a phase 3 glioma trial.2
Description	CAS Number: 1644545-52-7 Chemical Name: Isocitrate dehydrogenase (IDH) 1/2 inhibitor Molecular Weight: 414.74 Formula: C14H13ClF6N6 Solubility: DMSO (25 mg/ml) Physical Properties: White solid Purity: >98% by HPLC NMR (Conforms)