Ibrutinib

Overview
Catalog #	bs-83411c-50mg
Product Name	Ibrutinib
Specifications
Storage Buffer	White or off-white solid
Storage Condition	-20°C
Target
Product Information	Ibrutinib (936563-96-1) is a very potent (IC50 = 0.5nM) irreversible inhibitor of Bruton tyrosine kinase (BTK) that blocks activation of the B-cell antigen receptor (BCR).1 Ibrutinib also potently inhibits several other kinases including BLK, BMS, FGR, EGFR, and ITK. It is a clinically useful drug to treat B cell cancers. It inhibits CLL cell migration and survival2,3 and downregulates expression of CD204. It enhanced antitumor immune responses in combination with anti PD-L1 blockade via its inhibition of ITK (IL2-inducible T-cell kinase).5
Description	CAS Number: 936563-96-1 Chemical Name: BTK inhibitor Molecular Weight: 440.51 Formula: C25H24N6O2 Solubility: DMSO (>25 mg/ml) Physical Properties: White or off-white solid Purity: 99% by HPLC NMR (Conforms)